An immune-related lncRNA model for predicting prognosis, immune landscape and chemotherapeutic response in bladder cancer.

ABSTRACT: Long noncoding RNAs (lncRNAs) participate in cancer immunity. We characterized the clinical significance of an immune-related lncRNA model and evaluated its association with immune infiltrations and chemosensitivity in bladder cancer. Transcriptome data of bladder cancer specimens were employed from The Cancer Genome Atlas. Dysregulated immune-related lncRNAs were screened via Pearson correlation and differential expression analyses, followed by recognition of lncRNA pairs. Then, a LASSO regression model was constructed, and receiver operator characteristic curves of one-, three- and five-year survival were established. Akaike information criterion (AIC) value of one-year survival was determined as the cutoff of high- and low-risk subgroups. The differences in survival, clinical features,

SUBMITTER: Hou J 

PROVIDER: S-EPMC8881497 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature