Distinct cord blood C-peptide, adipokine, and lipidomic signatures by in utero HIV exposure.

ABSTRACT:

Background

Early-life metabolic derangements in HIV-exposed uninfected (HEU) infants have been reported.

Methods

Pregnant women with HIV and HIV-uninfected pregnant women were enrolled with their newborns in a US cohort from 2011 to 2015. We measured cord insulin, C-peptide, and metabolic cytokines of HEU and HIV-unexposed uninfected (HUU) newborns using ELISA and metabolites, lipid subspecies, and eicosanoids via liquid chromatography/mass spectrometry. Linear regression was employed to assess the association of intrauterine HIV/ART with insulin and C-peptide. Graphical lasso regression was used to identify differences between metabolite/lipid subspecies networks associated with C-peptide.

Results

Of 118 infants, 56 were HEU, ART exposed. In adjusted analyses, mean c

SUBMITTER: Jao J 

PROVIDER: S-EPMC8881568 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature