Increased retention of tau PET ligand [¹⁸F]-AV1451 in Alzheimer's Disease Psychosis.

ABSTRACT: Psychosis in Alzheimer's disease (AD) represents a distinct disease subtype with a more rapid progression of illness evidenced by an increased velocity of cognitive decline and a hastened mortality. Previous biomarker and post-mortem studies have implicated tau neuropathology as a possible mediator of the accelerated decline in AD psychosis. Tau positron emission tomography (PET) neuroimaging provides the opportunity to evaluate tau pathology in-vivo, so that clinical symptomatology can be correlated with disease pathology. [¹⁸F]-AV1451 (Flortaucipir) is a PET ligand with high affinity for insoluble paired-helical filaments (PHFs) of hyperphosphorylated tau. In order to determine whether the development of psychosis and worsened prognosis in AD is associated with an increased bu

SUBMITTER: Gomar JJ 

PROVIDER: S-EPMC8881582 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature