Different gut microbial communities correlate with efficacy of albendazole-ivermectin against soil-transmitted helminthiases.

ABSTRACT: Soil-transmitted helminth infections represent a large burden with over a quarter of the world's population at risk. Low cure rates are observed with standard of care (albendazole); therefore, a more effective combination therapy (albendazole and ivermectin) is being investigated but showed variable treatment efficacies without evidence of intrinsic parasite resistance. Here, we analyzed the microbiome of Trichuris trichiura and hookworm-infected patients and found an association of different enterotypes with treatment efficacy. 80 T. trichiura-infected patients with hookworm co-infections from Pak-Khan, Laos, received either albendazole (n = 41) or albendazole and ivermectin combination therapy (n = 39). Pre-/post-treatment stool samples were collected to monitor treatment efficacy and mi

SUBMITTER: Schneeberger PHH 

PROVIDER: S-EPMC8881608 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature