Lesion Evidence for a Causal Role of the Insula in Aversion to Social Inequity.

ABSTRACT: Humans resist unequal distributions of goods in their social interactions, even if it requires foregoing personal gains. Functional neuroimaging studies implicate the insula in this aversion to social inequity and in fairness-related decisions, but a causal contribution has not yet been established. We compared the responses of 30 patients with lesions to the insula on a multiple-trial version of the one-shot Ultimatum Game, a neuroeconomic social exchange paradigm where a sum of money is split between two players, to those of 30 matched patients with brain injuries sparing the insula. Insula lesion patients accepted offers of an unequal disadvantageous split significantly more often than comparison lesion patients. Computational modeling confirmed that this difference in choice behavior w

SUBMITTER: Nitsch FJ 

PROVIDER: S-EPMC8881633 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature