Radiation-induced Vascular Damage and the Impact on the Treatment Outcome of Stereotactic Body Radiotherapy.

ABSTRACT:

Background/aim

The aim of this study was to investigate radiation-induced tumour vascular damage and its impact thereof on the outcome of stereotactic body radiotherapy (SBRT).

Materials and methods

Vessel densities in animal tumours before and after a single dose of 20 Gy were quantified and used as input for simulations of three-dimensional tumours with heterogeneous oxygenation. SBRT treatments of the modelled tumours in 1-8 fractions were simulated. The impact of vessel collapse on the outcome of SBRT was investigated by calculating tumour control probability (TCP) and the dose required to obtain a TCP of 50% (D₅₀).

Results

A radiation-induced increase of acute hypoxia in tumours during SBRT treatment could be simulated based on the experimental data. T

SUBMITTER: Lindblom EK 

PROVIDER: S-EPMC8881796 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature