Design and various in silico studies of the novel curcumin derivatives as potential candidates against COVID-19 -associated main enzymes.

ABSTRACT: The novel coronavirus disease (COVID-19) is a highly contagious disease caused by the SARS-CoV-2 virus, leading severe acute respiratory syndrome in patients. Although various antiviral drugs and their combinations have been tried so far against SARS-CoV-2 and they have shown some effectiveness, there is still a need for safe and cost-effective binding inhibitors in the fight against COVID-19. Therefore, phytochemicals in nature can be a quick solution due to their wide therapeutic spectrum and strong antiviral, anti-inflammatory, and antioxidant properties. In this context, the low toxicity, and high pharmacokinetic properties of curcumin, which is a natural phytochemical, as well as the easy synthesizing of its derivatives reveal the need for investigation of its various derivatives as i

SUBMITTER: Alici H 

PROVIDER: S-EPMC8881819 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature