Sensitive and reproducible MEG resting-state metrics of functional connectivity in Alzheimer's disease.

ABSTRACT:

Background

Analysis of functional brain networks in Alzheimer's disease (AD) has been hampered by a lack of reproducible, yet valid metrics of functional connectivity (FC). This study aimed to assess both the sensitivity and reproducibility of the corrected amplitude envelope correlation (AEC-c) and phase lag index (PLI), two metrics of FC that are insensitive to the effects of volume conduction and field spread, in two separate cohorts of patients with dementia due to AD versus healthy elderly controls.

Methods

Subjects with a clinical diagnosis of AD dementia with biomarker proof, and a control group of subjective cognitive decline (SCD), underwent two 5-min resting-state MEG recordings. Data consisted of a test (AD = 28; SCD = 29) and validation (AD = 29; SCD = 27) cohort

SUBMITTER: Schoonhoven DN 

PROVIDER: S-EPMC8881826 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature