Dysbiosis of skin microbiome and gut microbiome in melanoma progression.

ABSTRACT:

Background

The microbiome alterations are associated with cancer growth and may influence the immune system and response to therapy. Particularly, the gut microbiome has been recently shown to modulate response to melanoma immunotherapy. However, the role of the skin microbiome has not been well explored in the skin tumour microenvironment and the link between the gut microbiome and skin microbiome has not been investigated in melanoma progression. Therefore, the aim of the present study was to examine associations between dysbiosis in the skin and gut microbiome and the melanoma growth using MeLiM porcine model of melanoma progression and spontaneous regression.

Results

Parallel analysis of cutaneous microbiota and faecal microbiota of the same individuals was performed in

SUBMITTER: Mekadim C 

PROVIDER: S-EPMC8881828 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature