Hif1α and Wnt are required for posterior gene expression during Xenopus tropicalis tail regeneration.

ABSTRACT: Regeneration of complex tissues is initiated by an injury-induced stress response, eventually leading to activation of developmental signaling pathways such as Wnt signaling. How early injury cues are interpreted and coupled to activation of these developmental signals and their targets is not well understood. Here, we show that Hif1α, a stress induced transcription factor, is required for tail regeneration in Xenopus tropicalis. We find that Hif1α is required for regeneration of differentiated axial tissues, including axons and muscle. Using RNA-sequencing, we find that Hif1α and Wnt converge on a broad set of genes required for posterior specification and differentiation, including the posterior hox genes. We further show that Hif1α is required for transcription via a Wnt-responsive elem

SUBMITTER: Patel JH 

PROVIDER: S-EPMC8881967 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature