Prognostic value of tumor markers and ctDNA in patients with resectable gastric cancer receiving perioperative treatment: results from the CRITICS trial.

ABSTRACT:

Aim

To evaluate the prognostic value of tumor markers in a European cohort of patients with resectable gastric cancer.

Methods

We performed a post hoc analysis of the CRITICS trial, in which 788 patients received perioperative therapy. Association between survival and pretreatment CEA, CA 19-9, alkaline phosphatase, neutrophils, hemoglobin and lactate dehydrogenase were explored in uni- and multivariable Cox regression analyses. Likelihoods to receive potentially curative surgery were investigated for patients without elevated tumor markers versus one of the tumor markers elevated versus both tumor markers elevated. The association between tumor markers and the presence of circulating tumor DNA (ctDNA) was explored in 50 patients with available ctDNA data.

Results

In

SUBMITTER: Slagter AE 

PROVIDER: S-EPMC8882113 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature