Selective serotonin reuptake inhibitors and suicidal behaviour: a population-based cohort study.

ABSTRACT: There is concern that selective serotonin reuptake inhibitor (SSRI) treatment may increase the risk of suicide attempts or deaths, particularly among children and adolescents. However, debate remains regarding the nature of the relationship. Using nationwide Swedish registers, we identified all individuals aged 6-59 years with an incident SSRI dispensation (N = 538,577) from 2006 to 2013. To account for selection into treatment, we used a within-individual design to compare the risk of suicide attempts or deaths (suicidal behaviour) in time periods before and after SSRI-treatment initiation. Within-individual incidence rate ratios (IRRs) of suicidal behaviour were estimated. The 30 days before SSRI-treatment initiation was associated with the highest risk of suicidal behaviour compared wit

SUBMITTER: Lagerberg T 

PROVIDER: S-EPMC8882171 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature