Identification of ∆9-tetrahydrocannabinol (THC) impairment using functional brain imaging.

ABSTRACT: The primary cannabinoid in cannabis, Δ9-tetrahydrocannabinol (THC), causes intoxication and impaired function, with implications for traffic, workplace, and other situational safety risks. There are currently no evidence-based methods to detect cannabis-impaired driving, and current field sobriety tests with gold-standard, drug recognition evaluations are resource-intensive and may be prone to bias. This study evaluated the capability of a simple, portable imaging method to accurately detect individuals with THC impairment. In this double-blind, randomized, cross-over study, 169 cannabis users, aged 18-55 years, underwent functional near-infrared spectroscopy (fNIRS) before and after receiving oral THC and placebo, at study visits one week apart. Impairment was defined by convergent classi

SUBMITTER: Gilman JM 

PROVIDER: S-EPMC8882180 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature