Network meta-analysis of transcriptome expression changes in different manifestations of dengue virus infection.

ABSTRACT:

Background

Several studies have been performed to study transcriptome profiles after dengue virus infections with partly different results. Due to slightly different settings of the individual studies, different genes and enriched gene sets are reported in these studies. The main aim of this network meta-analysis was to aggregate a selection of these studies to identify genes and gene sets that are more generally associated with dengue virus infection, i.e. with less dependence on the individual study settings.

Methods

We performed network meta-analysis by different approaches using publicly available gene expression data of five selected studies from the Gene Expression Omnibus database. The study network includes dengue fever (DF), hemorrhagic fever (DHF), shock syndrome (

SUBMITTER: Winter C 

PROVIDER: S-EPMC8882220 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature