Trajectories of Frailty With Aging: Coordinated Analysis of Five Longitudinal Studies.

ABSTRACT:

Background and objectives

There is an urgent need to better understand frailty and its predisposing factors. Although numerous cross-sectional studies have identified various risk and protective factors of frailty, there is a limited understanding of longitudinal frailty progression. Furthermore, discrepancies in the methodologies of these studies hamper comparability of results. Here, we use a coordinated analytical approach in 5 independent cohorts to evaluate longitudinal trajectories of frailty and the effect of 3 previously identified critical risk factors: sex, age, and education.

Research design and methods

We derived a frailty index (FI) for 5 cohorts based on the accumulation of deficits approach. Four linear and quadratic growth curve models were fit in each cohort

SUBMITTER: Jenkins ND 

PROVIDER: S-EPMC8882228 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature