LXR agonist improves peripheral neuropathy and modifies PNS immune cells in aged mice

ABSTRACT:

Background

Peripheral neuropathy is a common and progressive disorder in the elderly that interferes with daily activities. It is of importance to find efficient treatments to treat or delay this age-related neurodegeneration. Silencing macrophages by reducing foamy macrophages showed significant improvement of age-related degenerative changes in peripheral nerves of aged mice. We previously demonstrated that activation of the cholesterol sensor Liver X receptor (LXR) with the potent agonist, GW3965, alleviates pain in a diet-induced obesity model. We sought to test whether LXR activation may improve neuropathy in aged mice.

Methods

21-month-old mice were treated with GW3965 (25 mg/Kg body weight) for 3 months while testing for mechanical allodynia and thermal hyperalgesi

SUBMITTER: Gavini C 

PROVIDER: S-EPMC8882298 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature