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Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA.

ABSTRACT: Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to remove interstrand DNA cross-links (ICLs) from their genome but the identity of the naturally-occurring, endogenous substrates that drove the evolution and retention of these DNA repair systems across a wide range of life forms remains uncertain. In this review, we describe more than a dozen chemical processes by which endogenous ICLs plausibly can be introduced into cellular DNA. The majority involve DNA degradation processes that introduce aldehyde residues into the double helix or reactions of DNA with endogenous low molecular weight aldehyde metabolites. A smaller number of the cross-linking processes involve reactions of DNA radicals generated by oxidation.

SUBMITTER: Housh K

PROVIDER: S-EPMC8882318 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Formation and repair of unavoidable, endogenous interstrand cross-links in cellular DNA.

Housh Kurt K Jha Jay S JS Haldar Tuhin T Amin Saosan Binth Md SBM Islam Tanhaul T Wallace Amanda A Gomina Anuoluwapo A Guo Xu X Nel Christopher C Wyatt Jesse W JW Gates Kent S KS

DNA repair 20201224

Genome integrity is essential for life and, as a result, DNA repair systems evolved to remove unavoidable DNA lesions from cellular DNA. Many forms of life possess the capacity to remove interstrand DNA cross-links (ICLs) from their genome but the identity of the naturally-occurring, endogenous substrates that drove the evolution and retention of these DNA repair systems across a wide range of life forms remains uncertain. In this review, we describe more than a dozen chemical processes by which ...[more]

PMID: 33385969

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Formation and Repair of an Interstrand DNA Cross-Link Arising from a Common Endogenous Lesion.

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Correlation of Thermal Stability and Structural Distortion of DNA Interstrand Cross-Links Produced from Oxidized Abasic Sites with Their Selective Formation and Repair.

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