Multisite Study of Evoked Potentials in Rett Syndrome.

ABSTRACT:

Objective

The aim of the current study was to evaluate the utility of evoked potentials as a biomarker of cortical function in Rett syndrome (RTT). As a number of disease-modifying therapeutics are currently under development, there is a pressing need for biomarkers to objectively and precisely assess the effectiveness of these treatments.

Method

Yearly visual evoked potentials (VEPs) and auditory evoked potentials (AEPs) were acquired from individuals with RTT, aged 2 to 37 years, and control participants across 5 sites as part of the Rett Syndrome and Related Disorders Natural History Study. Baseline and year 1 data, when available, were analyzed and the repeatability of the results was tested. Two syndrome-specific measures from the Natural History Study were used for eva

SUBMITTER: Saby JN 

PROVIDER: S-EPMC8882338 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature