Can the lack of fibrillar form of alpha-synuclein in Lewy bodies be explained by its catalytic activity?

ABSTRACT: Finding the causative pathophysiological mechanisms for Parkinson's disease (PD) is important for developing therapeutic interventions. Until recently, it was believed that Lewy bodies (LBs), the hallmark of PD, are mostly composed of alpha-synuclein (α-syn) fibrils. Recent results (Shahmoradian et al. (2019)) demonstrated that the fibrillar form of α-syn is lacking from LBs. Here we propose that this surprising observation can be explained by the catalytic activity of the fibrillar form of α-syn. We assumed that α-syn fibrils catalyze the formation of LBs, but do not become part of them. We developed a mathematical model based on this hypothesis. By using the developed model, we investigated the consequences of this hypothesis. In particular, the model suggests that the long incubation ti

SUBMITTER: Kuznetsov IA 

PROVIDER: S-EPMC8882444 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature