The promising anti-virulence activity of candesartan, domperidone, and miconazole on Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is a primary cause of hospital and community-acquired infections. With the emergence of multidrug-resistant S. aureus strains, there is a need for new drugs discovery. Due to the poor supply of new antimicrobials, targeting virulence of S. aureus may generate weaker selection for resistant strains, anti-virulence agents disarm the pathogen instead of killing it. In this study, the ability of the FDA-approved drugs domperidone, candesartan, and miconazole as inhibitors of S. aureus virulence was investigated. The effect of tested drugs was evaluated against biofilm formation, lipase, protease, hemolysin, and staphyloxanthin production by using phenotypic and genotypic methods. At sub-inhibitory concentrations, candesartan, domperidone, and miconazole showed a significa

SUBMITTER: El-Ganiny AM 

PROVIDER: S-EPMC8882509 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature