A three-year longitudinal study of retinal function and structure in patients with multiple sclerosis.

ABSTRACT:

Background

Researchers have in recent years begun to investigate ophthalmological manifestations of multiple sclerosis (MS) other than optic neuritis (ON), and it is now clear that changes to retinal function (measured using the electroretinogram, ERG) and structure (measured using optical coherence tomography, OCT) are found in MS patients irrespective of prior ON episodes. ERG results are consistent with dysfunctional bipolar cells, as in other autoimmune diseases. To date, studies have presented only cross-sectional data regarding ERG and OCT. We, therefore, studied the longitudinal course of ERG and OCT in patients with MS, as well as the effect of disability changes and non-ON clinical relapses on these functional and structural measures.

Methods

MS patients (n = 23) pa

SUBMITTER: Hanson JVM 

PROVIDER: S-EPMC8882570 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature