Association Between Neuroticism and Risk of Lung Cancer: Results From Observational and Mendelian Randomization Analyses.

ABSTRACT:

Background

It remains undetermined whether neuroticism affects the risk of lung cancer. Therefore, we performed complementary observational and Mendelian randomization (MR) analyses to investigate the association between neuroticism and lung cancer risk.

Methods

We included 364,451 UK Biobank participants free of cancer at baseline. Neuroticism was ascertained using the 12-item of Eysenck Personality Inventory Neuroticism Scale. Multivariable Cox regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Two-sample MR analysis was carried out with summary genetic data from UK Biobank (374,323 individuals) and International Lung Cancer Consortium (29,266 lung cancer cases and 56,450 controls). Furthermore, we calculated a polygenic risk s

SUBMITTER: Wei X 

PROVIDER: S-EPMC8882734 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature