The Onset of Whole-Body Regeneration in Botryllus schlosseri: Morphological and Molecular Characterization.

ABSTRACT: Colonial tunicates are the only chordates that regularly regenerate a fully functional whole body as part of their asexual life cycle, starting from specific epithelia and/or mesenchymal cells. In addition, in some species, whole-body regeneration (WBR) can also be triggered by extensive injuries, which deplete most of their tissues and organs and leave behind only small fragments of their body. In this manuscript, we characterized the onset of WBR in Botryllus schlosseri, one colonial tunicate long used as a laboratory model. We first analyzed the transcriptomic response to a WBR-triggering injury. Then, through morphological characterization, in vivo observations via time-lapse, vital dyes, and cell transplant assays, we started to reconstruct the dynamics of the cel

SUBMITTER: Ricci L 

PROVIDER: S-EPMC8882763 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature