Systemic Radiopharmaceutical Therapy of Pheochromocytoma and Paraganglioma.

ABSTRACT: Whereas benign pheochromocytomas and paragangliomas are often successfully cured by surgical resection, treatment of metastatic disease can be challenging in terms of both disease control and symptom control. Fortunately, several options are available, including chemotherapy, radiation therapy, and surgical debulking. Radiolabeled metaiodobenzylguanidine (MIBG) and somatostatin receptor imaging have laid the groundwork for use of these radiopharmaceuticals as theranostic agents. ¹³¹I-MIBG therapy of neuroendocrine tumors has a long history, and the recent approval of high-specific-activity ¹³¹I-MIBG for metastatic or inoperable pheochromocytoma or paraganglioma by the U.S. Food and Drug Administration has resulted in general availability of, and renewed interest in, t

SUBMITTER: Carrasquillo JA 

PROVIDER: S-EPMC8882896 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature