Periconception and Prenatal Exposure to Maternal Perceived Stress and Cord Blood DNA Methylation.

ABSTRACT:

Background

Maternal prenatal stress is associated with physiologic and adverse mental health outcomes in the offspring, but the underlying biologic mechanisms are unknown. We examined the associations of maternal perceived stress, including preconception exposure, with DNA methylation (DNAm) alterations in the cord blood buffy coats of 358 singleton infants.

Methods

Maternal perceived stress was measured prior to and throughout pregnancy in a cohort of women enrolled in Effects of Aspirin in Gestation and Reproduction Trial (EAGeR) trial. Perceived stress assessments based on a standardized Likert-scale were obtained in periconception (~2 months preconception and 2-8 weeks of gestation) and pregnancy (8-36 weeks of gestation). Cumulative perceived stress was estimated by cal

SUBMITTER: Polinski KJ 

PROVIDER: S-EPMC8882928 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature