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In silico studies on structural inhibition of SARS-CoV-2 main protease M^pro by major secondary metabolites of Andrographis paniculata and Cinchona officinalis.

ABSTRACT: The COVID-19 infection by Novel Corona Virus (SARS-CoV-2) has become one of the largest pandemic diseases, with cumulative confirmed infections of 275,233,892 and 5,364,996 deaths to date according to World Health Organization. Due to the absence of any approved antiviral drug to treat COVID-19, its lethality is getting severe with time. The main protease of SARS-CoV-2, M^pro is considered one of the potential drug targets because of its role in processing proteins translated from viral RNA. In the present study, four of the plant metabolites, 14-deoxy-11,12-didehydroandrographolide, andrograpanin, quinine, cinchonine from two eminent medicinal plants Andrographis paniculata and Cinchona officinalis, have been evaluated against the main protease of SARS-CoV-2 through in

SUBMITTER: Majumdar M

PROVIDER: S-EPMC8883239 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Dataset Information

In silico studies on structural inhibition of SARS-CoV-2 main protease M^pro by major secondary metabolites of Andrographis paniculata and Cinchona officinalis.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

In silico studies on structural inhibition of SARS-CoV-2 main protease Mpro by major secondary metabolites of Andrographis paniculata and Cinchona officinalis.

OmicsDI is part of the ELIXIR infrastructure

Tweets

In silico studies on structural inhibition of SARS-CoV-2 main protease M^pro by major secondary metabolites of Andrographis paniculata and Cinchona officinalis.