Integrated analysis of the sialotranscriptome and sialoproteome of the rat flea Xenopsylla cheopis.

ABSTRACT: Over the last 20 years, advances in sequencing technologies paired with biochemical and structural studies have shed light on the unique pharmacological arsenal produced by the salivary glands of hematophagous arthropods that can target host hemostasis and immune response, favoring blood acquisition and, in several cases, enhancing pathogen transmission. Here we provide a deeper insight into Xenopsylla cheopis salivary gland contents pairing transcriptomic and proteomic approaches. Sequencing of 99 pairs of salivary glands from adult female X. cheopis yielded a total of 7432 coding sequences functionally classified into 25 classes, of which the secreted protein class was the largest. The translated transcripts also served as a reference database for the proteomic study, which identified pe

SUBMITTER: Lu S 

PROVIDER: S-EPMC8883501 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature