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Is developmental synchrony enabled by CTCF residence time?

ABSTRACT: Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation.

SUBMITTER: Wang HV

PROVIDER: S-EPMC8883576 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature

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Is developmental synchrony enabled by CTCF residence time?

Wang Hsiao-Lin V HV Corces Victor G VG

Developmental cell 20210901 18

Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation. ...[more]

PMID: 34582771

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