Is developmental synchrony enabled by CTCF residence time?

ABSTRACT: Depletion of CTCF in cultured cells has minor effects on transcription whereas its mutation leads to embryonic lethality and developmental defects. In a recent issue of Nature Cell Biology, Soochit et al. (2021) show that the residence time of CTCF on DNA may explain its critical role in cell differentiation.

SUBMITTER: Wang HV 

PROVIDER: S-EPMC8883576 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature