HiCBin: binning metagenomic contigs and recovering metagenome-assembled genomes using Hi-C contact maps.
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ABSTRACT:
SUBMITTER: Du Y
PROVIDER: S-EPMC8883645 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
HiCBin: binning metagenomic contigs and recovering metagenome-assembled genomes using Hi-C contact maps.
Genome biology 20220228 1
Recovering high-quality metagenome-assembled genomes (MAGs) from complex microbial ecosystems remains challenging. Recently, high-throughput chromosome conformation capture (Hi-C) has been applied to simultaneously study multiple genomes in natural microbial communities. We develop HiCBin, a novel open-source pipeline, to resolve high-quality MAGs utilizing Hi-C contact maps. HiCBin employs the HiCzin normalization method and the Leiden clustering algorithm and includes the spurious contact dete ...[more]
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