Construction and validation of a novel prognostic model for lung squamous cell cancer based on N6-methyladenosine-related genes.

ABSTRACT:

Background

N6-methyladenosine (m6A) is the most prevalent modification in mRNA in biological processes and associated with various malignant tumor initiation and progression. The present study aimed to construct a prognostic risk model based on m6A-related genes (the downstream genes influenced by m6A modulators) for LUSC.

Methods

Based on TCGA, we stratified LUSC patients with and without genetic alteration of m6A modulators into altered and unaltered groups. Using univariate Cox and Lasso regression analyses, we identified prognostic m6A-related genes to construct a prognostic risk model. We then applied a multivariate Cox proportional regression model and the survival analysis to evaluate the risk model. Moreover, we performed the Receiver operating characteristic curve t

SUBMITTER: Jia E 

PROVIDER: S-EPMC8883700 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature