Association between arthritis treatments and ovarian reserve: a prospective study.

ABSTRACT:

Research question

How do anti-Müllerian hormone (AMH) concentrations in women with and without arthritis compare? Is there an association between AMH and arthritis drug regimen?

Design

In this prospective cohort study, AMH was measured at two time points (T₀ and T₁) in 129 premenopausal women with arthritis. AMH at T₀ was compared with that from a bank of serum samples from 198 premenopausal women without arthritis. Primary outcomes were: (i) diminished ovarian reserve (DOR) (AMH <1.1 ng/ml) and (ii) annual rate of AMH decrease. Univariate, multivariable and Firth logistic regression identified variables associated with annual AMH decrease in excess of the 75th percentile.

Results

Median time between T₀ and T₁ was

SUBMITTER: Alexander VM 

PROVIDER: S-EPMC8884072 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature