Genetic Influence Underlying Brain Connectivity Phenotype: A Study on Two Age-Specific Cohorts.

ABSTRACT: Background: Human brain structural connectivity is an important imaging quantitative trait for brain development and aging. Mapping the network connectivity to the phenotypic variation provides fundamental insights in understanding the relationship between detailed brain topological architecture, function, and dysfunction. However, the underlying neurobiological mechanism from gene to brain connectome, and to phenotypic outcomes, and whether this mechanism changes over time, remain unclear. Methods: This study analyzes diffusion-weighted imaging data from two age-specific neuroimaging cohorts, extracts structural connectome topological network measures, performs genome-wide association studies of the measures, and examines the causality of genetic influences on phenotypic out

SUBMITTER: Cong S 

PROVIDER: S-EPMC8884108 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature