Ontogenetic Changes in Blood Osmolality During the Postembryonic Development of Zebrafish (Danio rerio).

ABSTRACT: The zebrafish Danio rerio is a teleost model species widely used in developmental genetics, biomedical studies, toxicology, and drug screening. Despite the interest of this species in research, little is known through indirect observations about its blood osmolality, which is a key parameter for diverse experiments. In this study, we directly measured blood osmolality using nano-osmometry at different stages of zebrafish postembryonic development. We found that blood osmolality is close to 240 mOsm·kg^-1 in early larvae. It progressively increased to ∼270 mOsm·kg^-1 during the larval development before reaching ∼300 mOsm·kg^-1 after metamorphosis in juveniles and later in adults. These ontogenetic changes in blood osmolality illustrate the physiological

SUBMITTER: Charmantier G 

PROVIDER: S-EPMC8884165 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature