Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.

ABSTRACT: Clinical, laboratory, and autopsy findings support an association between coronavirus disease-2019 (COVID-19) and thromboembolic disease. Acute COVID-19 infection is characterized by mononuclear cell reactivity and pan-endothelialitis, contributing to a high incidence of thrombosis in large and small blood vessels, both arterial and venous. Observational studies and randomized trials have investigated whether full-dose anticoagulation may improve outcomes compared with prophylactic dose heparin. Although no benefit for therapeutic heparin has been found in patients who are critically ill hospitalized with COVID-19, some studies support a possible role for therapeutic anticoagulation in patients not yet requiring intensive care unit support. We summarize the pathology, rationale, and curren

SUBMITTER: Farkouh ME 

PROVIDER: S-EPMC8884342 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature