Effects of selected inherited factors on susceptibility to SARS-CoV-2 infection and COVID-19 progression.

ABSTRACT: Genetic predispositions may influence geographical and interethnic differences in COVID-19 prevalence and mortality in affected populations. Of the many genes implicated in COVID-19 progression, a substantial number have no direct functional link on virus transfer/viability or on the host immune system. To address this knowledge deficit, a large number of in silico studies have recently been published. However, the results of these studies often contradict the findings of studies involving real patients. For example, the ACE2 has been shown to play an important role in regulating coronavirus entry into cells, but none of its variations have been directly associated with COVID-19 susceptibility or severity. Consistently was reported that increased risk of COVID-19 is associated with blood g

SUBMITTER: Hubacek JA 

PROVIDER: S-EPMC8884368 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature