Identifying Key Genes and Functionally Enriched Pathways of Diverse Adipose Tissue Types in Cattle.

ABSTRACT: Background: Fat is a tissue that not just stores energy and plays a protective role; it is also a vital endocrine organ that generates and integrates signals to influence metabolism. Meanwhile, the excessive accumulation of lipids in adipose tissue can lead to metabolic disturbance and diseases. To date, the complicated molecular mechanisms of bovine adipose tissue are still unknown. This study aimed to identify key genes and functionally enriched pathways in various adipose tissue types. Results: The RNAseq data of 264 samples were downloaded from Gene Expression Omnibus (GEO) and analyzed by weighted gene co-expression network analysis (WGCNA). We identified 19 modules that significantly associated with at least one adipose tissue type. The brown module from GSE39618 was mo

SUBMITTER: Pan C 

PROVIDER: S-EPMC8884536 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature