Genetic Effects of NDUFAF6 rs6982393 and APOE on Alzheimer's Disease in Chinese Rural Elderly: A Cross-Sectional Population-Based Study.

ABSTRACT:

Purpose

To investigate the associations of genotypes of NDUFAF6 rs6982393 and APOE and their combined genotypes with the risk of Alzheimer's disease (AD) and mild cognitive impairment (MCI) in Chinese rural elderly.

Methods

This cross-sectional population-based study included 5096 older adults (age ≥60 years, 57.1% female). Genotypes of NDUFAF6 rs6982393 and APOE were detected using the multiple-polymerase chain reaction amplification. We diagnosed AD following the criteria of Diagnostic and Statistical Manual of Mental Disorders, the fourth edition and diagnosed MCI following the Petersen's criteria MCI. Data were analyzed using the logistic regression model.

Results

The overall prevalence of AD and MCI was 3.57% (95% confidence interval [

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC8884707 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature