Reciprocally inhibitory circuits operating with distinct mechanisms are differently robust to perturbation and modulation.

ABSTRACT: Reciprocal inhibition is a building block in many sensory and motor circuits. We studied the features that underly robustness in reciprocally inhibitory two neuron circuits. We used the dynamic clamp to create reciprocally inhibitory circuits from pharmacologically isolated neurons of the crab stomatogastric ganglion by injecting artificial graded synaptic (I_Syn) and hyperpolarization-activated inward (I_H) currents. There is a continuum of mechanisms in circuits that generate antiphase oscillations, with 'release' and 'escape' mechanisms at the extremes, and mixed mode oscillations between these extremes. In release, the active neuron primarily controls the off/on transitions. In escape, the inhibited neuron controls the transitions. We characterized the robustness of

SUBMITTER: Morozova E 

PROVIDER: S-EPMC8884723 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature