A Novel Pyroptosis-Related Prognostic Signature for Cervical Squamous Cell Carcinoma.

ABSTRACT:

Purpose

Pyroptosis has vital roles in tumorigenesis and cancer development; however, its relationship with cervical squamous cell cancer (CSCC) remains unexplored. In this study, we aimed to develop a CSCC prediction signature related to pyroptosis.

Patients and methods

Consensus clustering analysis was conducted to detect pyroptosis-related subclusters for CSCC. Next, differentially expressed genes (DEGs) between subclusters were identified. Univariate, least absolute shrinkage and selection operator, and stepwise multivariate Cox regression analyses were applied to establish a prognostic model and a nomogram drawn. Additionally, functional enrichment analysis, tumor mutation burden, and immune characteristics associated with this signature were investigated.

Results

SUBMITTER: Ou T 

PROVIDER: S-EPMC8885126 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature