Hsa-miR-3651 could serve as a novel predictor for in-breast recurrence via FRMD3.

ABSTRACT:

Background

MicroRNAs are small non-coding RNAs with pivotal regulatory functions in multiple cellular processes. Their significance as molecular predictors for breast cancer was demonstrated in the past 15 years. The aim of this study was to elucidate the role of hsa-miR-3651 for predicting of local control (LC) in early breast cancer.

Results

By means of high-throughput technology, hsa-miR-3651 was found to be differentially expressed between patients who experienced local relapse compared to those without (N  =  23; p  =  0.0035). This result could be validated in an independent cohort of 87 patients using RT-qPCR (p  <  0.0005). In a second analysis step with a chip-based microarray containing 70,523 probes of potential target molecules, FERM domain protein 3 (FRMD3) was

SUBMITTER: Zellinger B 

PROVIDER: S-EPMC8885475 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature