Risk of extracolonic second primary cancers following a primary colorectal cancer: a systematic review and meta-analysis.

ABSTRACT:

Purpose

The purpose of the study is to assess the global risk of extracolonic secondary primary cancers (SPCs) in patients with colorectal cancer (CRC).

Methods

Studies of SPC in patients with CRC were included if they reported the standardised incidence ratio (SIR) for extracolonic SPCs in patients with CRC compared with the general population. Pooled summary estimates were calculated using a random-effects model.

Results

A total of 7,716,750 patients with CRC from 13 retrospective cohort studies that reported extracolonic SPC incidence were included. The overall risk of several SPCs was significantly higher in patients with CRC compared with the general population, including cancers of the urinary bladder (pooled SIR 1.19, 95% confidence interval (CI) 1.06-1.33; p =

SUBMITTER: Robertson D 

PROVIDER: S-EPMC8885556 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature