Differential DNA methylation in Black and White individuals with chronic low back pain enrich different genomic pathways.

ABSTRACT: Compared to Non-Hispanic Whites (NHWs), individuals who self-identify as Non-Hispanic Blacks (NHBs) in the United States experience more severe and disabling chronic low back pain (cLBP). We hypothesized that differences in DNA methylation (DNAm) play a role in racial disparities in cLBP.

Purpose

To determine the relationship between DNAm levels and racial group differences in adults with cLBP. Our study's secondary purpose was to perform a race-stratified comparison of adults with cLBP and pain-free controls and identify functional genomic pathways enriched by annotated differentially methylated genes.

Patients and methods

We recruited 49 NHBs and 49 NHWs (49 cLBP and 49 pain-free controls, PFCs), analyzed DNAm from whole blood using reduced representation bisulfite sequenci

SUBMITTER: Aroke EN 

PROVIDER: S-EPMC8885563 | biostudies-literature | 2022 Jan-Jul

REPOSITORIES: biostudies-literature