Gadolinium-Coated Mesoporous Silica Nanoparticle for Magnetic Resonance Imaging.

ABSTRACT: Magnetic resonance molecular imaging can provide anatomic, functional and molecular information. However, because of the intrinsically low sensitivity of magnetic resonance imaging (MRI), high-performance MRI contrast agents are required to generate powerful image information for image diagnosis. Herein, we describe a novel T ₁ contrast agent with magnetic-imaging properties facilitated by the gadolinium oxide (Gd₂O₃) doping of mesoporous silica nanoparticles (MSN). The size, morphology, composition, MRI relaxivity (r ₁ ), surface area and pore size of these nanoparticles were evaluated following their conjugation with Gd₂O₃ to produce Gd₂O₃@MSN. This unique structure led to

SUBMITTER: Li Z 

PROVIDER: S-EPMC8885602 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature