Dataset Information

Effects of curtailed sleep on cardiac stress biomarkers following high-intensity exercise.

ABSTRACT:

Objective

Physical exercise-especially at high intensity-is known to impose cardiac stress, as mirrored by, e.g., increased blood levels of cardiac stress biomarkers such as cardiac Troponin T (cTnT) and NT-proBNP. We examined healthy young participants to determine whether a few nights of short sleep duration alter the effects of acute exercise on these blood biomarkers.

Methods

Sixteen men participated in a randomized order in a crossover design, comprising three consecutive nights of a) normal sleep duration (NS, 8.5 h of sleep/night) and b) sleep restriction (SR, 4.25 h of sleep/night). Blood was repeatedly sampled for determination of NT-proBNP and cTnT serum levels before and after a high-intensity exercise protocol (i.e., 75% VO₂^maxReserve cycling on an ergometer).

Results

Under pre-exercise sedentary conditions, blood levels of cTnT and NT-proBNP did not significantly differ between the sleep conditions (P > 0.10). However, in response to exercise, the surge of circulating cTnT was significantly greater following SR than NS (+37-38% at 120-240 min post-exercise, P ≤ 0.05). While blood levels of NT-proBNP rose significantly in response to exercise, they did not differ between the sleep conditions.

Conclusion

Recurrent sleep restriction may increase the cardiac stress response to acute high-intensity exercise in healthy young individuals. However, our findings must be further confirmed in women, older subjects and in patients with a history of heart disease.

SUBMITTER: Martikainen T

PROVIDER: S-EPMC8885606 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

Effects of curtailed sleep on cardiac stress biomarkers following high-intensity exercise.

Martikainen Teemu T Sigurdardottir Fjola F Benedict Christian C Omland Torbjørn T Cedernaes Jonathan J

Molecular metabolism 20220126

<h4>Objective</h4>Physical exercise-especially at high intensity-is known to impose cardiac stress, as mirrored by, e.g., increased blood levels of cardiac stress biomarkers such as cardiac Troponin T (cTnT) and NT-proBNP. We examined healthy young participants to determine whether a few nights of short sleep duration alter the effects of acute exercise on these blood biomarkers.<h4>Methods</h4>Sixteen men participated in a randomized order in a crossover design, comprising three consecutive nig ...[more]

PMID: 35092845

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Dataset Information

Effects of curtailed sleep on cardiac stress biomarkers following high-intensity exercise.

Objective

Methods

Results

Conclusion

Publications

Effects of curtailed sleep on cardiac stress biomarkers following high-intensity exercise.

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