Positron emission tomography guided dose painting by numbers of lung cancer: Alanine dosimetry in an anthropomorphic phantom.

ABSTRACT:

Background and purpose

Dose painting by numbers (DPBN) require a high degree of dose modulation to fulfill the image-based voxel wise dose prescription. The aim of this study was to assess the dosimetric accuracy of ¹⁸F-fluoro-2-deoxy-glucose positron emission tomography(¹⁸F-FDG-PET)-based DPBN in an anthropomorphic lung phantom using alanine dosimetry.

Materials and methods

A linear dose prescription based on ¹⁸F-FDG-PET image intensities within the gross tumor volume (GTV) of a lung cancer patient was employed. One DPBN scheme with low dose modulation (Scheme A; minimum/maximum fraction dose to the GTV 2.92/4.26 Gy) and one with a high modulation (Scheme B; 2.81/4.52 Gy) were generated. The plans were transferred to a computed tomograpy (CT

SUBMITTER: Papoutsis I 

PROVIDER: S-EPMC8885607 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature