Dataset Information

Association between serum free hemoglobin level and cerebral white matter hyperintensity volume in older adults.

ABSTRACT: The association between serum free hemoglobin (sfHb) level and white matter hyperintensity (WMH) volume is controversial. This study is to examine this association considering nonlinearity, sex dimorphism, and WMH type. We enrolled 704 older adults among the participants of the Korean Longitudinal Study on Cognitive Aging and Dementia and visitors to the Dementia Clinic of Seoul National University Bundang Hospital. We measured sfHb level in the venous blood and WMH volume (V_WMH) using fluid-attenuated inversion recovery magnetic resonance images. The association between sfHb level and periventricular V_WMH was linear in men (linear regression; β = - 0.18, p = 0.006) and U-shaped in women (restricted cubic spline; F = 6.82, p < 0.001). sfHb level was not associated with deep V_WMH in either sex. These findings were also observed in participants without anemia. To conclude, sfHb level is associated with periventricular V_WMH in older adults of both sexes. Maintaining an optimal sfHb level may contribute to the prevention of WMH.

SUBMITTER: Oh DJ

PROVIDER: S-EPMC8885699 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Association between serum free hemoglobin level and cerebral white matter hyperintensity volume in older adults.

Oh Dae Jong DJ Kim Jun Sung JS Lee Subin S Yang Hee Won HW Bae Jong Bin JB Han Ji Won JW Kim Ki Woong KW

Scientific reports 20220228 1

The association between serum free hemoglobin (sfHb) level and white matter hyperintensity (WMH) volume is controversial. This study is to examine this association considering nonlinearity, sex dimorphism, and WMH type. We enrolled 704 older adults among the participants of the Korean Longitudinal Study on Cognitive Aging and Dementia and visitors to the Dementia Clinic of Seoul National University Bundang Hospital. We measured sfHb level in the venous blood and WMH volume (V<sub>WMH</sub>) usin ...[more]

PMID: 35228637

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Project description:Background and purposeWhite matter hyperintensities of presumed vascular origin in elderly patients with hypertension may be part of a general cerebral perfusion deficit, involving not only the white matter hyperintensities but also the surrounding normal-appearing white matter and gray matter. We aimed to study the relation between white matter hyperintensity volume and CBF and assess whether white matter hyperintensities are related to a general perfusion deficit.Materials and methodsIn 185 participants of the Prevention of Dementia by Intensive Vascular Care trial between 72 and 80 years of age with systolic hypertension, white matter hyperintensity volume and CBF were derived from 3D FLAIR and arterial spin-labeling MR imaging, respectively. We compared white matter hyperintensity CBF, normal-appearing white matter CBF, and GM CBF across quartiles of white matter hyperintensity volume and assessed the continuous relation between these CBF estimates and white matter hyperintensity volume by using linear regression.ResultsMean white matter hyperintensity CBF was markedly lower in higher quartiles of white matter hyperintensity volume, and white matter hyperintensity volume and white matter hyperintensity CBF were negatively related (standardized β = -0.248, P = .001) in linear regression. We found no difference in normal-appearing white matter or GM CBF across quartiles of white matter hyperintensity volume or any relation between white matter hyperintensity volume and normal-appearing white matter CBF (standardized β = -0.065, P = .643) or GM CBF (standardized β = -0.035, P = .382) in linear regression.ConclusionsHigher white matter hyperintensity volume in elderly individuals with hypertension was associated with lower perfusion within white matter hyperintensities, but not with lower perfusion in the surrounding normal-appearing white matter or GM. These findings suggest that white matter hyperintensities in elderly individuals with hypertension relate to local microvascular alterations rather than a general cerebral perfusion deficit.

Dataset Information

Association between serum free hemoglobin level and cerebral white matter hyperintensity volume in older adults.

Publications

Association between serum free hemoglobin level and cerebral white matter hyperintensity volume in older adults.

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