Biological Treatments and Target Therapies for Pediatric Respiratory Medicine: Not Only Asthma.

ABSTRACT: We present a description of pediatric pneumology biological medications and other target therapies. The article aims at introducing the importance of a molecular approach to improve treatments. The first item treated was T2-High asthma and its current biological treatment and prescribing indications to propose a flow-chart to guide the clinical choice. Molecular rationales of such treatments are used to introduce a more general description of the biological and molecular approach to target therapies application. We introduce a general interpretation approach to neutrophilic asthma using the molecular plausibility one in order to propose possible future treatments mainly targeting interleukin-1 (IL-1), IL-17, IL-12, and IL-23. Indeed, cytokines can be excellent targets for several biologica

SUBMITTER: Ghirardo S 

PROVIDER: S-EPMC8885732 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature