Association between olanzapine concentration and metabolic dysfunction in drug-naive and chronic patients: similarities and differences.

ABSTRACT: Second-generation antipsychotics are widely used to treat schizophrenia but their use could induce metabolic dysfunction. To balance efficacy and side effects, various guidelines recommend the use of therapeutic drug monitoring. Given the controversial relationship between olanzapine serum concentration and metabolic dysfunction, its use in clinical practice is still debated. To address this issue, we conducted a prospective cohort study to explore the associations in patients with schizophrenia. Specifically, first-episode drug-naive patients and patients with chronic schizophrenia were recruited. All participants received olanzapine monotherapy for 8 weeks. Anthropometric parameters and metabolic indices were tested at baseline and at week 8, and olanzapine serum concentration was tested

SUBMITTER: Kang D 

PROVIDER: S-EPMC8885747 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature