Clonal Hematopoiesis Is Associated With Higher Risk of Stroke.

ABSTRACT:

Background and purpose

Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was reported previously in an exploratory analysis including a small number of incident stroke cases without replication and lack of stroke subphenotyping. The purpose of this study was to discover whether CHIP is a risk factor for ischemic or hemorrhagic stroke.

Methods

We utilized plasma genome sequence data of blood DNA to identify CHIP in 78 752 individuals from 8 prospective cohorts and biobanks. We then assessed the association of CHIP and commonly mutated individual CHIP driver genes (DNMT3A, TET2, and ASXL1) with an

SUBMITTER: Bhattacharya R 

PROVIDER: S-EPMC8885769 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature