Whole-Genome Sequencing Association Analyses of Stroke and Its Subtypes in Ancestrally Diverse Populations From Trans-Omics for Precision Medicine Project.

ABSTRACT:

Background and purpose

Stroke is the leading cause of death and long-term disability worldwide. Previous genome-wide association studies identified 51 loci associated with stroke (mostly ischemic) and its subtypes among predominantly European populations. Using whole-genome sequencing in ancestrally diverse populations from the Trans-Omics for Precision Medicine (TOPMed) Program, we aimed to identify novel variants, especially low-frequency or ancestry-specific variants, associated with all stroke, ischemic stroke and its subtypes (large artery, cardioembolic, and small vessel), and hemorrhagic stroke and its subtypes (intracerebral and subarachnoid).

Methods

Whole-genome sequencing data were available for 6833 stroke cases and 27 116 controls, including 22 315 European, 787

SUBMITTER: Hu Y 

PROVIDER: S-EPMC8885789 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature